Endocrine Abstracts

Introduction: Pseudohypoaldosteronism type 2 (PHA2), also known as Gordon syndrome is a rare inherited form of low-renin hypertension associated with hyperkalaemia and hyperchloremic metabolic acidosis in patients with a normal glomerular filtration rate (GFR). PHA2 is the result of mutations in a family of serine-threonine kinases called with-no-lysine kinases (WNK) 1 and WNK4. These enzymes regulate electron channels in the aldosterone sensitive distal nephron, resulting in ...

Background: Previous nation-wide survey on iodine deficiency disorders (IDD) in Latvia showed a mild iodine deficiency in 587 schoolchildren (median UI – 59 μg/l). At the time less than 1% of all edible salt was iodized. Despite of the results of National IDD Elimination Committee study, all preventive measures were limited to production of leaflets promoting voluntary iodine salt consumption and convincing industry to use iodized salt. In order to perform a 10-year ...

Background: Many patients with type 2 diabetes (T2D) are not reaching glycemic targets even by using different combinations of antidiabetic drugs, including insulin. On the other hand, intensified multidrug therapy is associated with increased risk of severe side effects and individualized selection of medication is essential. The aim of our study is to evaluate efficiency of personalized pharmacotherapy according to the genotype and phenotype of T2D patients.<p class="abs...